Sibutramine boosts metabolism and therefore also calorie burning, and suppresses appetite. It used to go by the trade name Meridia. Sibutramine was fairly effective, but was banned after studies indicated that its use led to cardiovascular disease. When the Italians did their experiment, in which they gave 254 men and women with diabetes-2 a daily 10 mg sibutramine for a year, sibutramine was still a legal substance.

Because L-carnitine has theoretically purely beneficial effects for diabetes sufferers, the researchers wanted to learn about the effects of a combination of sibutramine and carnitine. So they gave half of their subjects sibutramine only, and the other half 2 g L-carnitine a day in addition.

In the course of the year the sibutramine group lost 9.1 kg; the carnitine-sibutramine group lost 10.9 kg. The combined group not only lost more weight, they also appeared to become more sensitive to insulin.

 HbA1c = glycated haemoglobin, a marker for diabetes; FPG = fasting plasma glucose; PPG = postprandial plasma glucose; HOMA-IR = homeostasis model assessment of insulin resistance index fasting plasma insulin.

 

 

L-carnitine supplementation resulted in an increased production of the ‘good’ fat cell hormone adiponectin, and reduced the production of the inflammatory factor TNF-alpha. This would suggest that L-carnitine reduced the inflammatory reactions that diabetes-2 causes.

 And there were no side effects among the group that were given L-carnitine. For the record: the research was not funded by an L-carnitine manufacturer, but by the university that employs the researchers.

Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients

Abstract

The aim of the study was to evaluate the effects of 12-month treatment with sibutramine plus l-carnitine compared with sibutramine alone on body weight, glycemic control, insulin resistance, and inflammatory state in type 2 diabetes mellitus patients. Two hundred fifty-four patients with uncontrolled type 2 diabetes mellitus (glycated hemoglobin [HbA1c] >8.0%) in therapy with different oral hypoglycemic agents or insulin were enrolled in this study and randomized to take sibutramine 10 mg plus l-carnitine 2 g or sibutramine 10 mg in monotherapy. We evaluated at baseline and after 3, 6, 9, and 12 months these parameters: body weight, body mass index, HbA1c, fasting plasma glucose, postprandial plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, leptin, tumor necrosis factor–α, adiponectin, vaspin, and high-sensitivity C-reactive protein. Sibutramine plus l-carnitine gave a faster improvement of fasting plasma glucose, postprandial plasma glucose, lipid profile, leptin, tumor necrosis factor–α, and high-sensitivity C-reactive protein compared with sibutramine alone. Furthermore, there was a better improvement of body weight, HbA1c, fasting plasma insulin, homeostasis model assessment of insulin resistance index, vaspin, and adiponectin with sibutramine plus l-carnitine compared with sibutramine alone. Sibutramine plus l-carnitine gave a better and faster improvement of all the analyzed parameters compared with sibutramine alone without giving any severe adverse effect.

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